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Updated weekly · Last refresh Aug 30

The Broad Institute Data Scientist Interview Questions

The questions to prepare for a The Broad Institute Data Scientist interview. Questions from real interview reports rank first. Updated weekly.

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~4htotal time
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1
MetricsStart here. 3 questions · ~24 min
2
Product Sense4 questions · ~33 min
Prioritize Features for a New ProductMedium

A framework for deciding which features should ship first when building a new product.

Feature PrioritizationUser Needsproduct developmentThe Broad Institute
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3
Statistics & Probability3 questions · ~24 min
Mean and Standard Deviation BasicsEasy

Compute the mean and standard deviation of a dataset, and distinguish the sample standard deviation from the population version.

DistributionsVarianceExpected ValueThe Broad Institute
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4
Machine Learning6 questions · ~49 min
Supervised vs Unsupervised LearningEasy

Explain how supervised and unsupervised learning differ, and ground the distinction in a practical ML example.

Unsupervised LearningFeature EngineeringBias-Variance TradeoffThe Broad Institute
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5
SQL & Data Manipulation3 questions + 3 drills · ~54 min
6
Behavioral & Leadership9 questions · ~73 min
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7
More topics4 questions · ~33 min
Pitfalls in Streaming Experiment AnalysisHard

Identify major online experiment pitfalls and explain how they can bias results in a streaming product A/B test.

Network InterferenceNovelty EffectSample Ratio MismatchThe Broad Institute
Evaluate Predictive Power of a ModelMedium

Assess whether a model has real predictive power using validation performance, calibration, and threshold behavior.

Cross-ValidationMAERMSEThe Broad Institute
Resolving Conflicting Data SourcesMedium

Tests data quality reasoning and reconciliation across heterogeneous sources.

Data WranglingDependenciesQualityThe Broad Institute
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