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Updated weekly · Last refresh Oct 17

The Broad Institute Data Scientist Interview Questions

The questions to prepare for a The Broad Institute Data Scientist interview. Questions from real interview reports rank first. Updated daily.

32questions
~5htotal time
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1
Statistics & ProbabilityStart here. 3 questions · ~26 min
2
Metrics3 questions · ~26 min
Diagnose a Performance DropHard

Investigate whether a performance decline is seasonal or a real product issue.

Leading IndicatorsDiagnosisTime SeriesThe Broad Institute
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3
Product Sense4 questions · ~34 min
Prioritize Features for a New ProductMedium

A framework for deciding which features should ship first when building a new product.

Feature PrioritizationUser Needsproduct developmentThe Broad Institute
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4
Machine Learning6 questions · ~51 min
Supervised vs Unsupervised LearningEasy

Explain how supervised and unsupervised learning differ, and ground the distinction in a practical ML example.

Unsupervised LearningFeature EngineeringBias-Variance TradeoffThe Broad Institute
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5
SQL & Data Manipulation3 questions + 2 drills · ~46 min
6
Behavioral & Leadership9 questions · ~77 min
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7
More topics4 questions · ~34 min
Evaluate Predictive Power of a ModelMedium

Assess whether a model has real predictive power using validation performance, calibration, and threshold behavior.

Cross-ValidationMAERMSEThe Broad Institute
Primary vs Guardrail MetricsEasy

Explain how a primary metric differs from a guardrail metric and how both are used in A/B test decisions.

ExperimentationGuardrail MetricsA/B TestingThe Broad Institute
Resolving Conflicting Data SourcesMedium

Tests data quality reasoning and reconciliation across heterogeneous sources.

Data WranglingDependenciesQualityThe Broad Institute
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The finish line: interview-readyComplete all 32 questions plus 2 hands-on drills to finish this plan.