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Updated weekly · Last refresh Oct 17

The Broad Institute Research Scientist Interview Questions

The questions to prepare for a The Broad Institute Research Scientist interview. Questions from real interview reports rank first. Updated daily.

50questions
~7htotal time
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1
Statistics & ProbabilityStart here. 3 questions · ~24 min
Statistical Methods in CV ProjectMedium

Assesses your statistical approach and ability to explain methods used in your work.

researchThe Broad Institute
Batch Effects and NormalizationMedium

Assesses statistical rigor for normalization and batch-effect mitigation in omics data.

normalizationThe Broad Institute
Statistical Methods for DataEasy

Tests your statistical literacy and ability to choose appropriate methods for research data.

ExperimentationRegressionHypothesis TestingThe Broad Institute
2
Machine Learning6 questions · ~48 min
Defend Experimental DesignHard

Evaluates your ability to justify experimental design decisions under rigorous scrutiny.

critical thinkingexperimental designmethodologyThe Broad Institute
Exploratory Analysis for Novel DataMedium

Evaluates your approach to exploratory analysis under ambiguity and limited metadata.

Data AnalysismethodologyThe Broad Institute
Supervised vs Unsupervised MLMedium

Evaluates your ability to match ML methods to biological research goals.

Unsupervised LearningSupervised LearningThe Broad Institute
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3
Behavioral & Leadership40 questions · ~320 min
Explaining Your Calculation ApproachEasy

Tests structured quantitative communication under uncertainty, including how you explain assumptions, stay organized, and self-correct.

interview preparationProblem SolvingcalculationsThe Broad Institute
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4
More topics1 question · ~8 min
Ensuring ReproducibilityMedium

Tests rigor in experimental design, documentation, and controls for repeatable research results.

experimental designreproducibilityevaluation frameworkThe Broad Institute
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