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Validate Generalization Across Hospitals

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Problem

Scenario

You have trained a medical imaging model and now need to show that its performance will hold up when data comes from different hospitals or scanner vendors. The team is concerned that a strong internal validation result may not reflect real-world variation in patient mix, acquisition protocols, and device settings.

Question

How would you validate a model so that it generalizes across different hospitals or imaging devices?

What this tests

  • Cross-site validation strategy
  • AUC-ROC interpretation across subgroups
  • Calibration across hospitals
  • Confusion matrix tradeoffs at deployment thresholds