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Tuning Microsoft Defender for Endpoint

MediumSecurity & Infrastructure00:00
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Your question is Tuning Microsoft Defender for Endpoint. Take a moment with it on the right.

Talk me through your thinking if you like. When you're confident, submit your answer and I'll grade it like a real screen (7/10 or better passes).

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Problem

How would you approach configuring and tuning Microsoft Defender for Endpoint (MDE) to minimize CPU and memory contention on end-user systems?