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Prep plan
Updated weekly · Last refresh Aug 30

Syneos Health Data Scientist Interview Questions

The questions to prepare for a Syneos Health Data Scientist interview. Questions from real interview reports rank first. Updated weekly.

50questions
~7htotal time
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1
SQL & Data ManipulationStart here. 6 questions + 1 drill · ~61 min
2
Model Evaluation7 questions · ~60 min
Choose AUC-ROC or F1Medium

Compare two classifiers with similar AUC-ROC but different F1 at an operating threshold, and explain when each metric should drive decisions.

F1 ScorePrecisionAUC-ROCSyneos Health
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3
Machine Learning6 questions · ~51 min
Handle Highly Imbalanced ClassesMedium

Build a classifier for a highly imbalanced dataset and choose training and evaluation methods that surface rare positives.

Cross-ValidationFeature EngineeringSupervised LearningSyneos Health
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4
Pipelines5 questions · ~43 min
Handling Missing Data in PipelinesMedium

Approach for handling missing data in an ML data pipeline, including validation, imputation, and safe downstream consumption.

InfrastructureETLBatch ProcessingSyneos Health
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5
Product Sense6 questions · ~51 min
Prioritize Features for a New ProductMedium

A framework for deciding which features should ship first when building a new product.

Feature PrioritizationUser Needsproduct developmentSyneos Health
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6
Statistics & Probability6 questions · ~51 min
Statistical Significance in Business DecisionsEasy

Explain what statistical significance means, how p-values and confidence intervals support decisions, and why significance alone is not enough.

Hypothesis TestingStatistical SignificanceP-ValuesSyneos Health
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7
More topics14 questions · ~120 min
Planning Sample Size for a Conversion TestHard

Estimate sample size and power for a conversion experiment with a pre-registered analysis plan and guardrail-based ship rule.

MDEPower AnalysisSample SizeSyneos Health
Defining Trial Performance Success MetricsMedium

Tests translating business and clinical goals into measurable success metrics.

KPIsLeading IndicatorsDiagnosisSyneos Health
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The finish line: interview-readyComplete all 50 questions plus 1 hands-on drill to finish this plan.