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Prep plan
Updated weekly · Last refresh Aug 30

Genentech Machine Learning Engineer Interview Questions

The questions to prepare for a Genentech Machine Learning Engineer interview. Questions from real interview reports rank first. Updated weekly.

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1
Machine LearningStart here. 6 questions · ~48 min
Handle Highly Imbalanced ClassesMedium

Build a classifier for a highly imbalanced dataset and choose training and evaluation methods that surface rare positives.

Cross-ValidationFeature EngineeringSupervised LearningGenentech
Active Learning for Lead SelectionHard

Tests your ability to design data-efficient ML loops for Genentech-like compound prioritization and experimentation.

experiment designactive learningGenentech
GNN vs Equivariant Message PassingHard

Tests your depth of understanding of GNN formulations and equivariance properties relevant to molecular and structural data.

Genentech
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2
Behavioral & Leadership11 questions · ~88 min
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3
More topics5 questions · ~40 min
Scalable Training for Billions of ParametersHard

Tests your system design and distributed training knowledge for very large ML models.

InfrastructureFeature StoreModel ServingGenentech
Metric Limitations and MitigationMedium

Tests your judgment in selecting metrics for scientific ML and your ability to reduce evaluation bias or blind spots.

Evaluation TechniquesModel MetricsGenentech
Autoregressive vs Masked Protein ModelingMedium

Tests your understanding of sequence modeling choices and their impact on protein representation learning.

Language ModelsGenentech
Optimizing PyTorch Molecular Data LoadingHard

Tests your performance engineering skills for ML pipelines handling large molecular datasets at scale.

data loadingInfrastructureperformanceGenentech
Generative Modeling for Binding AffinityHard

Tests your ability to transfer modeling approaches to a Genentech-relevant target and define a practical training plan.

Genentech

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