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Calico Life Sciences Interview Questions

The questions to prepare for Calico Life Sciences interviews, across all roles. Questions from real interview reports rank first. Updated weekly.

50questions
~7htotal time
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1
CodingStart here. 3 questions · ~25 min
Decision Tree From ScratchHard
Practice

Implement a CART-style decision tree from scratch using Gini impurity, recursive splitting, and deterministic predictions.

RecursionTreesDecision TreesCalico Life Sciences
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2
Machine Learning7 questions · ~59 min
Supervised vs Unsupervised LearningEasy

Explain how supervised and unsupervised learning differ, and ground the distinction in a practical ML example.

Unsupervised LearningFeature EngineeringBias-Variance TradeoffCalico Life Sciences
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3
Metrics4 questions · ~34 min
Define Success for a ProjectEasy

Define what success means for a project using clear KPIs, a north star, and supporting metrics.

KPIsSuccess CriteriaDiagnosisCalico Life Sciences
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4
Execution7 questions · ~59 min
Prioritize Across Competing Data ProjectsEasy

Explain how you prioritize across multiple concurrent data engineering projects with competing stakeholder needs and limited capacity.

Trade-offsRoadmappingScope ManagementCalico Life Sciences
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5
Pipelines4 questions · ~34 min
Data Quality and Schema EvolutionMedium

Approach for handling schema changes and data quality checks in a high-volume data lake pipeline.

schema evolutionData ModelingQualityCalico Life Sciences
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6
Statistics & Probability7 questions · ~59 min
Statistical Project WalkthroughMedium

Walk through a past project using hypothesis testing and regression to turn data into a decision.

RegressionHypothesis TestingStatistical SignificanceCalico Life Sciences
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7
More topics18 questions · ~152 min
Tell Me About YourselfEasy

Tests your ability to deliver a clear, relevant introduction tailored to the role at Aqr.

Competitive AnalysisGo-to-MarketCalico Life Sciences
K-Neighbor Numbers in Sorted ListHard

Evaluates algorithmic thinking and boundary handling for efficient data retrieval.

CodingCalico Life Sciences
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Hands-on SQL practiceWrite and run real queries in the editor. 3 drills · ~30 min
Monthly Sales Trends by CategoryMedium
Practice
Practice drill

Aggregate monthly sales by product category and use LAG to calculate month-over-month changes.

InfrastructureToolsData WranglingTotal Wine & MoreInc.Benjamin Moore
Handle Missing Financial Input ValuesMedium
Practice
Practice drill

Use joins, CTEs, and CASE logic to flag and fill missing financial fields for Qlik planning records.

Data WranglingETLQualityQlik
Contact Center Agent Performance MetricsHard
Practice
Practice drill

Compute daily agent call KPIs and SLA using joins, aggregations, and window ranking in a contact center model.

ETLAggregationsData ModelingADP
The finish line: interview-readyComplete all 50 questions plus 3 hands-on drills to finish this plan.