10x Genomics Research Scientist Interview Questions

The questions to prepare for a 10x Genomics Research Scientist interview. Questions from real interview reports rank first. Updated daily.

34questions

~5htotal time

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Machine LearningStart here. 8 questions · ~64 min

Evaluates your grounding in relevant protocol chemistry and molecular biology for 10x Genomics assays.

Controlled Experiments With VariablesMedium

Assesses your experimental design rigor and how you manage tradeoffs across variables.

experimental designProblem Solving

10x Genomics

Assay Development and OligosMedium

Tests your ability to describe assay development work and optimize oligonucleotide-related steps.

10x Genomics

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Model Evaluation10 questions · ~80 min

Tests ability to analyze NGS data end-to-end and quantify assay performance reliably.

Biological Signal vs Technical ArtifactHard

Tests ability to reason about confounders and technical failure modes in assay outputs.

CalibrationAccuracyThreshold Tuning

10x Genomics

Spatial Transcriptomics Signal ValidationHard

Tests expertise in diagnosing artifacts versus real biology in spatially resolved transcriptomics.

CalibrationAccuracyThreshold Tuning

10x Genomics

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Behavioral & Leadership14 questions · ~112 min

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More topics2 questions · ~16 min

Python or R for NGS AnalysisMedium

Tests your ability to apply scripting for early NGS data QC, interpretation, and decision support.

Hash TablesArraysSorting

10x Genomics

Optimize Assays with DoEHard

Tests ability to use DoE to efficiently optimize assay performance for commercial single-cell and spatial workflows.

ExperimentationRegressionHypothesis Testing

10x Genomics

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