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SQL Join for Mutation Frequencies
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SQL Join for Mutation Frequencies

MediumSQL · PostgreSQL

Problem

Write a SQL query to join clinical patient tables with genetic test results, filtering for specific mutation frequencies across multiple cohorts.

Return qualifying results where mutation frequency is between 0.01 and 0.05, inclusive, and the mutation appears in at least two distinct cohorts.

Output

  1. One row per qualifying patient mutation result, with patient_id, patient_name, cohort_name, mutation_code, and mutation_frequency.
  2. Include only mutations meeting the frequency and multi-cohort requirements.
  3. Order by mutation_code, cohort_name, and patient_id ascending.

Schema

clinical_patients
ColumnTypeDescription
patient_idPKINTUnique clinical patient identifier
patient_nameVARCHAR(100)Patient display name
cohort_idINTClinical cohort assigned to the patient
indicationVARCHAR(100)Clinical indication associated with the patient
cohorts
ColumnTypeDescription
cohort_idPKINTUnique cohort identifier
cohort_nameVARCHAR(100)Cohort name
study_codeVARCHAR(30)Study code associated with the cohort
genetic_test_results
ColumnTypeDescription
result_idPKINTUnique genetic test result identifier
patient_idINTPatient associated with the test result
mutation_codeVARCHAR(30)Mutation identifier
mutation_frequencyDECIMAL(6,5)Observed mutation frequency
test_dateDATEDate the genetic test was performed
Tablesclinical_patientscohortsgenetic_test_results
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