Your question is Handling Ad Hoc DMC Requests. Take a moment with it on the right.
Talk me through your thinking if you like. When you're confident, submit your answer and I'll grade it like a real screen (7/10 or better passes).
How would you handle a situation where a DMC asked for additional ad hoc analyses, including changes to scope and timelines?
Explain how you would distinguish pre-specified, safety-critical, and exploratory analyses; document requested changes; assess their statistical and operational consequences; and communicate trade-offs to the DMC. Address how you would protect the primary estimand, control false-positive risk, revisit power and MDE assumptions, and decide whether the timeline can change. Your response should include an analysis-plan amendment process, treatment of multiple comparisons and interim looks, and a clear recommendation framework for proceeding, extending, or stopping the work.